Loss of CD11b Exacerbates Murine Complement-Mediated Tubulointerstitial Nephritis
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چکیده
منابع مشابه
Loss of CD11b Exacerbates Murine Complement-Mediated Tubulointerstitial Nephritis
Acute complement activation occurs in the tubulointerstitium (TI) of kidneys transplanted from Crry(-/-)C3(-/-) mice into complement-sufficient wildtype mice, followed by marked inflammatory cell infiltration, tubular damage and interstitial fibrosis. We postulated iC3b-CD11b interactions were critical in this TI nephritis model. We transplanted Crry(-/-)C3(-/-) mouse kidneys into CD11b(-/-) an...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0092051